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Title   사지 연부 육종에 대한 기능 보존적 절제 수술과 외부 방사선치료 및 근접자입 방사선치료의 적용 ( Limb - Conserving Surgery and Interstitial Brachytherapy Plus External Radiation Therapy in Extremity Soft Tissue Sarcoma )
Publicationinfo   1998 Jan; 030(03): 599-608.
Key_word   Extremity soft tissue sarcoma, Brachytherapy, Limb-conserving surgery
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Abstract   Purpose: In order to avoid functional disability that may be caused by radical excision or amputation in extremity soft tissue sarcomas, authors employed limb-conserving surgery together with extemal radiation therapy plus interstitial brachytherapy. Materials and Methods: From June 1995 to Febrary 1997, 10 extremity soft tissue sarcoma patients were treated with limb-conserving surgery and external radiation therapy plus interstitial brachytherapy. In six patients, whose histologic diagnoses were made at the time of surgery, wide or marginal excision and interstitial brachytherapy was done 4 weeks before postoperative external radiation therapy. In four patients whose histologic confinnations were done before definitive treatment, preoperative external radiation therapy was given 4 weeks before surgery and interstitial brachytherapy. The types of surgery were wide excision in five patients, and marginal excision in five patients. Gross or microscopic residual was left at the surgical resection margins in four patients. The brachytherapy dose ranged from 17.5 Gy to 24 Gy and external beam radiation did from 40 Gy to 45 Gy. Results: With the median follow-up duration of 21.5 months(range: 13 to 29 months); one local recurrence, and three new distant metastases were observed. There were three patients with wound complications attributable to the current treatment regimen. Conclusion: Satisfactory local tumor control may be achievable with limb-conserving surgery and external radiation therapy plus brachytherapy in patients with extremity soft tissue sarcomas, while more caution should be used to avoid wound problems.
저 자   안용찬(Yong Chan Ahn),임도훈(Do Hoon Lim),서재곤(Jai Gon Seo),김문경(Moon Kyung Kim),우홍균(Hong Gyun Wu),김대용(Dae Young Kim),허승재(Seung Jae Huh)